Etiology and Pathogenesis of Osteochondrosis

@article{Ytrehus2007EtiologyAP,
  title={Etiology and Pathogenesis of Osteochondrosis},
  author={Bj{\o}rnar Ytrehus and Cathy S Carlson and Stina Ekman},
  journal={Veterinary Pathology},
  year={2007},
  volume={44},
  pages={429 - 448}
}
Osteochondrosis is a common and clinically important joint disorder that occurs in human beings and in multiple animal species, most commonly pigs, horses, and dogs. This disorder is defined as a focal disturbance of enchondral ossification and is regarded as having a multifactorial etiology, with no single factor accounting for all aspects of the disease. The most commonly cited etiologic factors are heredity, rapid growth, anatomic conformation, trauma, and dietary imbalances; however, only… Expand
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It is speculated that an altered type II collagen metabolism may be involved in the early changes associated with OC, and further studies of OC susceptible animals in utero and the first weeks of life are required to elucidate the cause of vessel necrosis and the exact role oftype II collagen structure and metabolism. Expand
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: This review is focused on osteochondrosis (OC) in horses. OC is a disturbance in endochondral ossification of mutifactorial etiology affecting equines and other animal species. There is no… Expand
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Although its impact on the performance of affected horses has not been demonstrated in every breed or in all types of osteochondrosis, the lower sales value of affected animals and/or their not being approved for breeding purposes are actually issues. Expand
Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy
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It would be important to provide more information on the exact pathophysiological mechanism(s) underlying early OC(D) lesions, in order to implement innovative strategies involving the use of progenitor stem cells, which are considered nowadays as a promising approach to regenerative medicine. Expand
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Twenty years ago a supplement of Equine Veterinary Journal was devoted to equine osteochondrosis (OC) and recognised the importance of this developmental disease to the equine industry. In the… Expand
Delayed endochondral ossification in early medial coronoid disease (MCD): a morphological and immunohistochemical evaluation in growing Labrador retrievers.
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Investigation of early micromorphological changes occurring in articular cartilage and the postnatal development of the medial coronoid process (MCP) before MCD demonstrated that MCD was initially associated with a disturbance of endochondral ossification. Expand
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