Etiologies underlying sex differences in Autism Spectrum Disorders
@article{Schaafsma2014EtiologiesUS, title={Etiologies underlying sex differences in Autism Spectrum Disorders}, author={Sara M. Schaafsma and Donald W. Pfaff}, journal={Frontiers in Neuroendocrinology}, year={2014}, volume={35}, pages={255-271} }
141 Citations
Sex-specific gene–environment interactions underlying ASD-like behaviors
- Biology, PsychologyProceedings of the National Academy of Sciences
- 2017
It was found that LPS-induced maternal immune activation caused male-specific deficits in certain social responses in the contactin-associated protein-like 2 mouse model for ASD, providing proof-of-principle that genetic and environmental factors interact to cause sex-specific effects that may help explain the male bias in ASD incidence.
Sex Differences in Autism Spectrum Disorder: a Review
- Biology, PsychologyCurrent Psychiatry Reports
- 2018
Current findings and theories that contribute to male preponderance of neurodevelopmental disorders, with a focus on autism are reviewed, and the possibilities of female underdiagnosis and a multi-hit hypothesis are discussed.
Incidence and Characteristics of ASD
- Biology, Psychology
- 2021
Emerging evidence suggests that the placenta may be particularly important as a mediator of the actions of environmental and endocrine risk factors on the developing brain, with the male being particularly sensitive to these effects.
Sex/gender differences in neurology and psychiatry: Autism.
- Psychology, BiologyHandbook of clinical neurology
- 2020
Genes and sex hormones interaction in neurodevelopmental disorders
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2016
Biological factors underlying sex differences in neurological disorders.
- Psychology, BiologyThe international journal of biochemistry & cell biology
- 2015
Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism
- Biology, PsychologyMolecular Autism
- 2015
It is suggested that disruption of Rora/RORA expression may have a greater impact on males, since sex differences in the correlation of R ORA and target gene expression indicate that RORA-deficient males may experience greater dysregulation of genes relevant to ASD in certain brain regions during development.
The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications
- Biology
- 2017
The current literature regarding the epigenetic changes involved in ASD is reviewed, including their possible mechanisms of action such as oxidative stress, altered fatty acid metabolism, mitochondrial dysfunction, DNA methylation and histone methylation (via the one‐carbon metabolism cycle), histone variants, and ATP‐dependent chromatin remodeling.
Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders
- Biology, MedicineBrain sciences
- 2017
ERβ’s recent discovery in directing DNA de-methylation to specific sites, of which one such site may bear consequences for the susceptibility to the neurological reading disorder dyslexia, are discussed.
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