• DOI:10.1016/j.yfrne.2014.03.006
Corpus ID: 7636860

Etiologies underlying sex differences in Autism Spectrum Disorders

@article{Schaafsma2014EtiologiesUS,
  title={Etiologies underlying sex differences in Autism Spectrum Disorders},
  author={S. M. Schaafsma and D. Pfaff},
  journal={Frontiers in Neuroendocrinology},
  year={2014},
  volume={35},
  pages={255-271}
}

S. M. Schaafsma, D. Pfaff

Published 2014

Biology, Medicine

Frontiers in Neuroendocrinology

The male predominance of Autism Spectrum Disorders (ASD) is one of the best-known, and at the same time, one of the least understood characteristics of these disorders. In this paper we review genetic, epigenetic, hormonal, and environmental mechanisms underlying this male preponderance. Sex-specific effects of Y-linked genes (including SRY expression leading to testicular development), balanced and skewed X-inactivation, genes that escape X-inactivation, parent-of-origin allelic imprinting… CONTINUE READING

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