Etiologies of Sarcoidosis

@article{Chen2015EtiologiesOS,
  title={Etiologies of Sarcoidosis},
  author={Edward S. Chen and David R. Moller},
  journal={Clinical Reviews in Allergy & Immunology},
  year={2015},
  volume={49},
  pages={6-18}
}
Since sarcoidosis was first described more than a century ago, the etiologic determinants causing this disease remain uncertain. Studies suggest that genetic, host immunologic, and environmental factors interact together to cause sarcoidosis. Immunologic characteristics of sarcoidosis include non-caseating granulomas, enhanced local expression of T helper-1 (and often Th17) cytokines and chemokines, dysfunctional regulatory T-cell responses, dysregulated Toll-like receptor signaling, and… CONTINUE READING

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