Etiologic Pathogenesis of Melanoma

@article{Meyskens2004EtiologicPO,
  title={Etiologic Pathogenesis of Melanoma},
  author={Frank L. Meyskens and Patrick J. Farmer and Hoda Anton-Culver},
  journal={Clinical Cancer Research},
  year={2004},
  volume={10},
  pages={2581 - 2583}
}
Melanoma is the eighth most common malignancy in the United States and has shown rapid increases in its incidence rate over the past two decades, especially in early-stage disease [(1][1], [2][2], [3][3], [4)][4] . A recent analysis of data from the Surveillance Epidemiology and End Results Program 
Melanoma and Other Cutaneous Malignancies
TLDR
This chapter focuses primarily on melanoma, but a discussion of other cutaneous malignancies is included. Expand
Melanoma from Molecular Pathways to Clinical Treatment: An Up to Date Review
TLDR
The combination of macrophage activation and other treatments such as immunotherapy, surgery, chemotherapy, and radiotherapy, may provide an effective and comprehensive anti-melanoma strategy. Expand
Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances
TLDR
The aim of this review is to consolidate and present the data related to the aetiology and pathogenesis of cutaneous melanoma, thus rendering them easier to understand. Expand
New perspectives on melanoma pathogenesis and chemoprevention.
TLDR
Observations that elevation of reactive oxygen species follows from melanin serving as a redox generator may play an important role in the etiology and pathogenesis of cutaneous melanoma offer a new paradigm for the development of preventive (and therapeutic) approaches to this disease. Expand
Translational research in melanoma.
TLDR
There has been a fervent attempt to identify novel approaches to melanoma therapy and translate them into clinical use to reduce the chance of recurrence after surgery and for treating unresectable disease. Expand
Diet and melanoma in a case-control study.
  • F. Meyskens, P. Farmer, H. Anton-Culver
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2005
TLDR
Several dietary compounds associated with a lower risk of melanoma and alcohol as a factor associated with an increased risk are identified and a biological explanation for these findings is offered. Expand
Skin Cancer Prevention
Nonmelanoma skin cancer (NMSC) is the most common malignancy in the world, and the incidence continues to increase worldwide. It has been estimated that over three million new skin cancer cases occurExpand
Melanoma molecular subtypes: unifying and paradoxical results.
TLDR
Further evidence that molecular subtypes of malignant melanoma may develop along divergent pathways is provided and the authors did not find an association between somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status. Expand
Gender Differences in Melanoma Progression and Survival
markdownabstract__Abstract__ Cutaneous melanoma is developing into a major public health problem worldwide. Incidence differs greatly across the world with high incidence rates in the UnitesExpand
Targeting events in melanoma carcinogenesis for the prevention of melanoma
TLDR
The data for several promising agents, including statins, curcumin, resveratrol, silymarin and green tea, are reviewed, and some importance issues and concepts that should be considered in any melanoma chemoprevention strategy are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
[Epidemiology of malignant melanoma].
TLDR
Melanoma was not registered in the aborigines living in the north of the Territory, and skin melanoma predominated in patients with the light-color skin. Expand
The melanoma epidemic: res ipsa loquitur.
TLDR
The melanoma epidemic has arisen for a variety of reasons including: a true increase in melanomas of malignant behavior, a particularly high increase in localized and in situ lesions, and an increase in the number of biopsies performed, which may have resulted in an increased detection of less aggressive lesions. Expand
Epidemiology of malignant melanoma.
TLDR
Although a dramatic decline is not expected in melanoma rates immediately, continuous preventive efforts ultimately should lead to a reduction in incidence and mortality. Expand
Melanoma etiology: where are we?
TLDR
A new measure of sun exposure, based on individual residential history, confers substantially increased risk of melanoma in European, North American, and Australian populations, and the presence of clinically identified dysplastic nevi confers greatly increased risk. Expand
Striking increase of thin melanomas contrasts with stable incidence of thick melanomas.
TLDR
A striking increase in incidence of thin melanomas contrasts with a stable incidence of thick melanomas is found, and the evolution of tumor thickness is studied. Expand
Chemoprevention of melanoma: an unexplored strategy.
  • M. Demierre, L. Nathanson
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2003
TLDR
Melanoma, with its associated risk factors and its known precursors or premalignant lesions, should lend itself well to chemoprevention and recent information should stimulate research in the chemoplevention of melanoma. Expand
Analysis of the melanoma epidemic, both apparent and real: data from the 1973 through 1994 surveillance, epidemiology, and end results program registry.
TLDR
Examination of changes in melanoma rates by several measures of severity of disease indicates that the increasing incidence rates are not solely caused by increased early detection and diagnosis of clinically insignificant melanomas, but may also represent a true increase in cancer rates. Expand
The melanoma epidemic : Is increased surveillance the solution or the problem ?
TLDR
It is not clear whether the increase in the number of melanoma cases diagnosed reflects an actual increase in real disease, and could this increase be in part a product of aggressive surveillance resulting in the identification of "atypical" pigmented skin tumors of limited or nonexistent potential for malignant behavior. Expand
High frequency of BRAF mutations in nevi
TLDR
It is suggested that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis. Expand
Nonfamilial cutaneous melanoma incidence in women associated with sun exposure before 20 years of age.
TLDR
A nested case-control analysis was conducted within the Nurses' Health Study cohort to examine the relation between timing of severe sun exposure and incidence of melanoma and no material association was found between blistering sunburns after 30 years of age and melanoma. Expand
...
1
2
3
4
5
...