Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme.

@article{Pirrung1998EthyleneBP,
  title={Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme.},
  author={Michael C. Pirrung and J Cao and Jianhua Chen},
  journal={Chemistry & biology},
  year={1998},
  volume={5 1},
  pages={49-57}
}
BACKGROUND The chemical mechanism of the final step of ethylene biosynthesis (the conversion of 1-aminocyclopropanecarboxylic acid, ACC, to ethylene by ACC oxidase, the ethylene-forming enzyme, EFE) is poorly understood. Two possibilities have been suggested: a radical mechanism and an N-hydroxylation mechanism. We investigated reaction pathways available to radical intermediates in this reaction using an ACC analog, 1-aminocyclobutanecarboxylic acid (ACBC) as a substrate. RESULTS ACBC was… CONTINUE READING