Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress.

@article{Li2012EthylPR,
  title={Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress.},
  author={Li-Fu Li and K I Kao and Cheng-Ta Yang and Chung-Chi Huang and Yung-Yang Liu},
  journal={Experimental biology and medicine},
  year={2012},
  volume={237 6},
  pages={720-7}
}
Mechanical ventilation with high tidal volume causes intense inflammatory responses and oxidative stress, including the release of high-mobility group box-1 (HMGB1), plasminogen activator inhibitor-1 (PAI-1) and heme oxygenase-1 (HO-1). The mechanisms regulating ventilator-induced lung injury (VILI) are unclear. We hypothesized that ethyl pyruvate… CONTINUE READING