Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.

@article{Paola2009EthylPR,
  title={Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.},
  author={Rosanna di Paola and Emanuela Mazzon and T. Genovese and Concetta Crisafulli and Placido Bramanti and Rocco Caminiti and Emanuela Esposito and Mitchell P. Fink and Salvatore Cuzzocrea},
  journal={Critical care medicine},
  year={2009},
  volume={37 1},
  pages={270-82}
}
OBJECTIVE Ethyl pyruvate (EP) is a simple aliphatic ester, which has been shown to have anti-inflammatory effects in previous numerous cell culture and animal studies. In the present study, we investigated the effects of EP (75 mg/kg i.p.) on the development of shock caused by zymosan. DESIGN Prospective, randomized study. SETTING University-based research laboratory. SUBJECTS Male CD mice. INTERVENTIONS Mice received either intraperitoneally zymosan (500 mg/kg, administered i.p. as a… CONTINUE READING

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