Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model

@inproceedings{Shang2009EthylPR,
  title={Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model},
  author={Guan-Hong Shang and Dian-jie Lin and Wei Xiao and Chong-qi Jia and Yu Li and Ai-Hua Wang and Liang Dong},
  booktitle={Respiratory research},
  year={2009}
}
BACKGROUND Ethyl pyruvate (EP) was recently identified as an experimental therapeutic agent in a wide variety of model systems for inflammation-mediated tissue and cellular injury. OBJECTIVE To evaluate the effect of ethyl EP on improving the survival in mice with LPS-induced acute lung injury (ALI). METHODS ALI was induced by administering lipopolysaccharide (LPS) intratracheally. The mice were treated intraperitoneally (i.p.) with 100, 50 and 10 mg/kg EP immediately before intratracheal… CONTINUE READING