Ethyl phosphoramidates of acyclovir: design, synthesis, molecular docking (HN Protein), and evaluation of antiviral and antioxidant activities

Abstract

Synthesis of a series of new ethyl phosphoramidates 9a–j of acyclovir through phosphorylation of hydroxy group followed by substitution of numerous amines/amino acid esters 7a–j was accomplished. The structures of newly synthesized compounds were elucidated by spectroscopic data such as IR, NMR (1H, 13C, and 31P) and mass spectrophotometery, and elemental… (More)
DOI: 10.1007/s00044-017-1819-8

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