Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet.

@article{Nemoto2009EthyleicosapentaenoicAR,
  title={Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet.},
  author={Nahoko Nemoto and Satoe Suzuki and Hiroyuki Kikuchi and Hitomi Okabe and Shuji Sassa and Shoichi Sakamoto},
  journal={In vivo},
  year={2009},
  volume={23 5},
  pages={
          685-9
        }
}
Fatty liver disease is characterized by a wide spectrum of liver damage, i.e. simple steatosis may progress to advanced fibrosis and to cryptogenic cirrhosis via steatohepatitis, and ultimately to hepatocellular carcinoma. Eicosapentaenoic acid (EPA), a marine-derived n-3 fatty acid like docosahexaenoic acid (DHA), is an anti-thrombotic and hypolipidemic agent, and is an antagonist of platelet aggregation and an inhibitor of cholesterol and lipoprotein. In an attempt to confirm the… CONTINUE READING