Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems.

@article{Yamamoto1990EthylCM,
  title={Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems.},
  author={Takahiro Yamamoto and William M. Pierce and H. E. Lionel Hurst and Dandan Chen and William J. Waddell},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1990},
  volume={18 3},
  pages={276-80}
}
The metabolism of ethyl carbamate and the localization of its metabolites have been shown to be almost completely inhibited by ethanol in the mouse [Waddell, Marlowe, Pierce: Food Chem. Toxicol.25, 527 (1987); Yamamoto, Pierce, Hurst, Chen, Waddell: Drug Metab. Dispos. 16, 355 (1988)]. The enzyme system catalyzing this metabolism which is inhibited by ethanol now has been further investigated in both in vivo and in vitro studies. There is a direct, highly significant relationship between the… CONTINUE READING

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