Ethyl alcohol enhances plasminogen activator secretion by endothelial cells.

@article{Laug1983EthylAE,
  title={Ethyl alcohol enhances plasminogen activator secretion by endothelial cells.},
  author={Walter E. Laug},
  journal={JAMA},
  year={1983},
  volume={250 6},
  pages={772-6}
}
Confluent cultures of cloned bovine endothelial cells, which were derived from large vessels, produced and secreted plasminogen activator (PA) at constant rates. Exposure of these cultures to increasing concentrations of ethyl alcohol resulted in a significant augmentation of PA production and secretion. This effect, which was observed after three hours and was maximal after 18 hours of incubation, was abolished by simultaneous exposure of the cultures to cycloheximide, indicating that active… CONTINUE READING

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