Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats

@article{Godinho2018EthylacetateFO,
  title={Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats},
  author={Jacqueline Godinho and R. M. W. Oliveira and Anacharis Babeto de S{\'a}-Nakanishi and Cristiano Correia Bacarin and Humberto Milani},
  journal={Behavioural Brain Research},
  year={2018},
  volume={337},
  pages={173-182}
}
We originally reported that an ethyl-acetate fraction (EAF) of Trichilia catigua prevented the impairment of water maze learning and hippocampal neurodegeneration after transient global cerebral (TGCI) in mice. We extended that previous study by evaluating whether T. catigua (i) prevents the loss of long-term retrograde memory assessed in the aversive radial maze (AvRM), (ii) confers hippocampal and cortical neuroprotection, and (iii) mitigates oxidative stress and neuroinflammation in rats… CONTINUE READING

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