Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles.

@article{Hodgetts2002Ethyl2A,
  title={Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles.},
  author={K. Hodgetts and Mark T. Kershaw},
  journal={Organic letters},
  year={2002},
  volume={4 17},
  pages={
          2905-7
        }
}
  • K. Hodgetts, Mark T. Kershaw
  • Published 2002
  • Medicine, Chemistry
  • Organic letters
    • [reaction: see text] By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions, the synthesis of variously substituted oxazoles from ethyl 2-chlorooxazole-4-carboxylate (2) was accomplished. The methodology was applied to the synthesis of a series of 2,4-disubstituted, 2,5-disubstituted, and 2,4,5-trisubstituted oxazoles. 
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