Ethoxylated alcohol (Neodol-12) and other surfactants in the assay of protein kinase C.

  title={Ethoxylated alcohol (Neodol-12) and other surfactants in the assay of protein kinase C.},
  author={T. F. Abidi and C. A. Faaland and D. D. Scala and L. D. Rhein and J. Laskin},
  journal={Biochimica et biophysica acta},
  volume={992 3},
  • T. F. Abidi, C. A. Faaland, +2 authors J. Laskin
  • Published 1989
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • Most commonly used surfactants were found to be inhibitors of partially purified rat brain protein kinase C at or above their critical micellar concentrations (CMC). These include sodium lauryl sulfate, deoxycholate, octyl glucoside, dodecyl trimethylammonium bromide, linear alkylbenzene sulfonate and Triton X-100. Several detergents, including the nonionic surfactants digitonin and Neodol-12 (ethoxylated alcohol), did not inhibit protein kinase C activity, even at concentrations greater than… CONTINUE READING
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