Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze

@article{Cole1995EthologicalCO,
  title={Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze},
  author={Jonathan C Cole and Robert James Rodgers},
  journal={Pharmacology Biochemistry and Behavior},
  year={1995},
  volume={52},
  pages={473-478}
}
Recent clinical evidence suggests that the tricyclic antidepressant imipramine is effective against not only panic disorder but also generalized anxiety disorder. Although most animal models of anxiety appear to be insensitive to this agent, such work has almost invariably employed an acute treatment regimen. In the present study, ethological methods have been used to assess in detail the effects of acute and chronic imipramine treatment on the behaviour of male DBA/2 mice in the elevated plus… CONTINUE READING
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