Ethnic variations of a retinoblastoma susceptibility gene (RB1) polymorphism in eight Asian populations

  title={Ethnic variations of a retinoblastoma susceptibility gene (RB1) polymorphism in eight Asian populations},
  author={Priya Kadam-Pai and Xin-Yi Su and Jasmin Jiji Miranda and Agustinus Soemantri and N. Banerjee Saha and Chew-Kiat Heng and P S Lai},
  journal={Journal of Genetics},
An A → G single nucleotide polymorphism (SNP) at nucleotide 153,104 in the retinoblastoma susceptibility locus (RB1) at 13q14 was previously reported to be present only in Asians. In this study, we determined the distribution of this SNP in normal Southeast Asian populations (Chinese, Malay, Javanese, Thai, Filipino), in South Asian populations (Bangladeshi, Pakistani Pushtun and Indian) and in Chinese retinoblastoma cases and control subjects. TheRB1 SNP was present in all populations at an… CONTINUE READING

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