Ethnic differences in nicotine metabolic rate among New Zealanders.

  title={Ethnic differences in nicotine metabolic rate among New Zealanders.},
  author={Rod A. Lea and Neal Benowitz and Michael B. Green and Jeff Fowles and Anasuya Vishvanath and Stuart Dickson and Marino Lea and Alistair Woodward and Geoffrey Chambers and D. Phillips},
  journal={The New Zealand medical journal},
  volume={118 1227},
AIMS To estimate (a) the prevalence of gene variants associated with slow nicotine metabolism in the general Maori population and (b) nicotine intake and metabolic rate in Maori and European smokers. METHODS The procedure involved (a) genotyping 85 Maori participants for cytochrome P-450 2A6 (CYP2A6) gene variants, which are associated with reduced nicotine metabolic rate (ie CYP2A6*9 and *4); and (b) measuring salivary cotinine (COT) and trans-3'-hydroxycotinine (3-HC) as biomarkers of… CONTINUE READING
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