Ethnic differences in drug metabolism and toxicity from chemotherapy.

  title={Ethnic differences in drug metabolism and toxicity from chemotherapy.},
  author={Viet Hong Phan and Melissa M. Moore and Andrew J. McLachlan and Micheline Piquette-Miller and Hongmei Xu and Stephen J. Clarke},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={5 3},
There is wide inter-individual variability in the pharmacokinetics, pharmacodynamics and tolerance of anticancer drugs. Recent evidence suggests that there is even greater variability between individuals of different ethnicity. Allelic variants of genes encoding drug metabolising enzymes are expressed with different incidences in different ethnic groups, particularly between Asian and Caucasians, and some of these variants result in altered enzyme function. There is also preliminary evidence to… CONTINUE READING

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