Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome.

@article{Ackerman2003EthnicDI,
  title={Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome.},
  author={Michael J. Ackerman and David Tester and Gregg S. Jones and Melissa L. Will and Christopher R. Burrow and Mark E. Curran},
  journal={Mayo Clinic proceedings},
  year={2003},
  volume={78 12},
  pages={1479-87}
}
OBJECTIVE To determine the spectrum, frequency, and ethnic-specificity of channel variants in the potassium channel genes implicated in congenital long QT syndrome (LQTS) among healthy subjects. SUBJECTS AND METHODS Genomic DNA from 744 apparently healthy individuals-305 black, 187 white, 134 Asian, and 118 Hispanic--was subject to a comprehensive mutational analysis of the 4 LQTS-causing potassium channel genes: KCNQ1 (LQT1), KCNH2 (LQT2), KCNE1 (LQT5), and KCNE2 (LQT6). RESULTS Overall… CONTINUE READING
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