Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine.

@article{Kurnik2008EthnicAG,
  title={Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine.},
  author={Daniel Kurnik and Mordechai Muszkat and Gbenga G. Sofowora and Eitan A. Friedman and William D. Dupont and Mika Scheinin and Alastair J. J. Wood and Charles M. Stein},
  journal={Hypertension},
  year={2008},
  volume={51 2},
  pages={406-11}
}
The alpha(2)-adrenoceptor agonist clonidine reduces blood pressure more effectively in White than Black Americans despite similar degrees of sympatholysis. Functional genetic variation in receptor signaling mechanisms, for example in the beta 3 G-protein subunit (GNB3 C825T) and in the alpha(2C)-adrenoceptor subtype (ADRA2C del322-325), may affect drug responses. We examined the hypothesis that there are ethnic differences in the responses to the highly selective alpha(2)-agonist… CONTINUE READING

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