Ethnic Related Selection for an ADH Class I Variant within East Asia

Abstract

BACKGROUND The alcohol dehydrogenases (ADH) are widely studied enzymes and the evolution of the mammalian gene cluster encoding these enzymes is also well studied. Previous studies have shown that the ADH1B*47His allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele… (More)
DOI: 10.1371/journal.pone.0001881

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