Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes.

@article{Mayol1992EthinylEC,
  title={Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes.},
  author={Xavier Mayol and Gregory Edward Neal and Reginald Davies and Alexandre Romero and Josep Domingo},
  journal={Carcinogenesis},
  year={1992},
  volume={13 12},
  pages={2381-8}
}
Hepatocyte proliferation was analyzed in vivo during the time course of continuous administration to rats of the liver tumor promoter ethinyl estradiol (EE) at 10 p.p.m. in the diet. EE-induced acute liver hyperplasia was detected in male and female Sprague-Dawley rats as an increased mitotic index of hepatocytes after 2 days of treatment. 5'-Bromodeoxyuridine (BrdU) labeling showed that proliferating hepatocytes were randomly distributed throughout the hepatic lobule. Subsequently, and still… CONTINUE READING
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