Ethical issues in human genome research

@article{Murray1991EthicalII,
  title={Ethical issues in human genome research},
  author={Thomas H. Murray},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={55 - 60}
}
  • T. Murray
  • Published 1 January 1991
  • Biology, Medicine
  • The FASEB Journal
In addition to provocative questions about science policy, research on the human genome will generate important ethical questions in at least three categories. First, the possibility of greatly increased genetic information about individuals and populations will require choices to be made about what that information should be and about who should control the generation and dissemination of genetic information. Presymptomatic testing, carrier screening, workplace genetic screening, and testing… Expand

Topics from this paper

Social Attitudes and the Human Genome Project: Ethical Implications
The international effort of the Human Genome Project (HGP), which seeks to map and sequence all of the estimated 3 billion bp that make up the human genome, is expected to provid,;: information inExpand
Genetic Testing at the Workplace: Scientific, Legal and Ethical Considerations
This article examines the various scientific, legal, and ethical issues involved in genetic testing at the workplace. On the basis of this examination, the adequacy of current policies to deal withExpand
ETHICS IN BIOTECHNOLOGY
TLDR
The most modern techniques in biotechnology owe their existence to the discovery of DNA cloning and the genetic manipulation of organisms and it is not possible to make general statements on the safety of all GM foods. Expand
Ethics Instruction in an Issues-Oriented Course on Public Health Genetics
  • S. Modell, T. Citrin
  • Sociology, Medicine
  • Health education & behavior : the official publication of the Society for Public Health Education
  • 2002
TLDR
The ethics component of an “Issues in Public Health Genetics” course uniting the fields of genetics, ethics, and public health is described, emphasizing the translation of ethical-social issues into substantive policies. Expand
Playing With Fire: The Ethics of Germ Line Genetic Therapy
TLDR
This paper reviews the major issues that should be ad-dressed in order to properly deal with the ethical dilemmas that may arise from the use of germ line genetic therapy. Expand
Regulatory Concerns with Gene Therapy and Recombinant Therapeutic Proteins
TLDR
Pharmaceutical scientists need to include healthcare policy makers in their audience to reduce the barriers to entry into the global market for innovative products such as gene therapy. Expand
Ethical concerns of medical profession
Ethical principles along with legal systems are the most potent regulators of man’s behavior in collecti­ ve life. They are two basic drives of civilization. Author gives a short analysis ofExpand
Apolipoprotein E and Alzheimer's disease: the implications of progress in molecular medicine.
TLDR
The use of apolipoprotein E genotyping in patients with Alzheimer's disease should be limited to research centers, and additional studies are strongly recommended, while genotypic risks are fully understood. Expand
The potential social impact of predictive genetic testing for susceptibility to common chronic diseases: a review and proposed research agenda.
TLDR
Current knowledge about the social and cultural impact of providing people with information relating to their risk for future disease is reviewed, focusing not only on currently available predictive genetic testing but also on hypertension, hyperlipidaemia and cancer screening. Expand
Technology, policy, ethics, and public health: a select bibliography
  • H. Tavani
  • Engineering, Computer Science
  • IEEE Technol. Soc. Mag.
  • 2000
TLDR
The enclosed bibliography, which includes nearly 400 entries, identifies sources that examine technology and policy issues associated with public health and selected sources on ethical theory and its application. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Who's afraid of the human genome?
  • G. Annas
  • Sociology, Medicine
  • The Hastings Center report
  • 1989
TLDR
It is argued that the human genome project has been overhyped and oversold, that the legal and ethical issues posed by the project are real and unappreciated, and that the dangers as well as the opportunities should be rigorously and publicly explored. Expand
Human gene therapy: scientific and ethical considerations.
  • W. Anderson
  • Psychology, Medicine
  • The Journal of medicine and philosophy
  • 1985
TLDR
In order to provide guidelines for determining when germ line gene therapy would be ethical, the author presents three criteria which should be satisfied prior to the time that a clinical protocol is attempted in humans. Expand
Warning: screening workers for genetic risk.
  • T. Murray
  • Medicine
  • The Hastings Center report
  • 1983
TLDR
The author proposes "least restrictive alternative" policies for each type of program, and presents a list of conditions to be met to achieve a morally defensible policy. Expand
Presymptomatic testing for Huntington's disease.
TLDR
A presymptomatic test for HD is sought by those at risk and should be made available with proper safeguards to protect confidentiality, and testing should be offered in a setting that provides diverse and continuing support. Expand
The American Society of Human Genetics statement on cystic fibrosis screening.
TLDR
It will be appropriate to begin large-scale population screening in the foreseeable future, once the test detects a larger proportion of CF carriers and more information is available regarding the issues surrounding the screening process, but until that time, it is considered premature to undertake population screening. Expand
The cystic fibrosis gene: medical and social implications for heterozygote detection.
TLDR
Implementation of population screening should be delayed until pilot studies that demonstrate its safety and effectiveness are completed, and preconception testing should be offered to adult relatives of cystic fibrosis patients as part of a comprehensive program following institutional review board approval. Expand
Preliminary results may open door to gene therapy just a bit wider.
THE DOOR that leads to true gene therapy appears to have been opened a little wider by the finding that tumor-infiltrating lymphocytes armed with a marker gene can survive in a patient for at leastExpand
Abortion: Law, Choice and Morality
TLDR
The medical, legal, and theological aspects of abortion as they exist in the various parts of the world are reviewed, citing the changing frequency and usage of these designations in support of the termination of pregnancy. Expand
Finding the gene(s) for alcoholism.
TLDR
A surprisingly strong association between an allele of the dopamine D 2 receptor and alcoholism is reported, which is provocative and promising but must be regarded with caution. Expand
Identification of the cystic fibrosis gene: chromosome walking and jumping.
TLDR
Several transcribed sequences and conserved segments were identified in this cloned region and one corresponds to the cystic fibrosis gene and spans approximately 250,000 base pairs of genomic DNA. Expand
...
1
2
3
...