Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit

Alzheimer's disease (AD) is among the most significant health care burdens. Disappointing results from clinical trials in late-stage AD persons combined with hopeful results from trials in persons with early-stage suggest that research in the preclinical stage of AD is necessary to define an optimal therapeutic success window. We review the justification… CONTINUE READING

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