Ether lipid (AMG) exhibits both synergistic and inhibitory interactions with the ionophore A23187 in mast cell histamine release.

Antineoplastic ether lipids with the structure 1-O-long-chain-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) have direct tumour cytotoxic as well as immunomodulatory effects. Their tumouricidal action has been related to protein kinase C inhibition by the dialkylglycerol metabolite (AMG). The present investigation explores the influence of AMG (1-O… CONTINUE READING