Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice.

@article{Mahesh2013EthanolicEO,
  title={Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice.},
  author={Bandari Uma Mahesh and Shweta Shrivastava and Madhusudhana Kuncha and Bidya Dhar Sahu and Challa Veerabhadra Swamy and Rajeswara Rao Pragada and V. G. M. Naidu and Ramakrishna Sistla},
  journal={Environmental toxicology and pharmacology},
  year={2013},
  volume={36 3},
  pages={840-9}
}
The aim of the study was to investigate the potential protective effect of ethanolic extract of Boswellia ovalifoliolata (BO) bark and leaf against doxorubicin (DOX)-induced cardiotoxicity in mice. Ethanolic extracts of BO bark (400 mg/kg) and leaves (250 mg/kg) were given orally to mice for 9 consecutive days and DOX (15 mg/kg; i.p.) was administered on the seventh day. Extract protected against DOX-induced ECG changes. It significantly inhibited DOX-provoked glutathione depletion and… CONTINUE READING