Ethanol withdrawal reduces the number of spontaneously active ventral tegmental area dopamine neurons in conscious animals.

@article{Shen2003EthanolWR,
  title={Ethanol withdrawal reduces the number of spontaneously active ventral tegmental area dopamine neurons in conscious animals.},
  author={Roh-Yu Shen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 2},
  pages={
          566-72
        }
}
Withdrawal from chronic ethanol treatment leads to a reduction in the electrical activity in dopamine (DA) neurons in the ventral tegmental area (VTA). However, there is disagreement on how the electrical activity is reduced (i.e., in the number of spontaneously active DA neurons or their firing rates and burst firing activity) and on the underlying mechanisms. The use of general anesthesia has been suggested to cause this discrepancy. In the present study, we demonstrate that ethanol… CONTINUE READING

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