Ethanol upregulates iNOS expression in colon through activation of nuclear factor-kappa B in rats.

@article{Wang2010EthanolUI,
  title={Ethanol upregulates iNOS expression in colon through activation of nuclear factor-kappa B in rats.},
  author={Chao Wang and Shuanglian Wang and Junfang Qin and Yinglian Lv and Xuelian Ma and Chuanyong Liu},
  journal={Alcoholism, clinical and experimental research},
  year={2010},
  volume={34 1},
  pages={
          57-63
        }
}
BACKGROUND Alcohol inhibits colonic motility but the mechanism is unknown. The goal of this study was to test the possibility that nuclear factor-kappa B (NF-kappaB) is involved in the upregulation of inducible nitric oxide synthase (iNOS) expression induced by ethanol in colon. METHODS The isometric contraction of longitudinal muscle strips of proximal colon (LP) was monitored by polygraph. Western blot analysis was used to measure the amount of iNOS and I-kappaB in the cytoplasm and P65 in… CONTINUE READING