Ethanol targets: a BK channel cocktail in C. elegans.

  title={Ethanol targets: a BK channel cocktail in C. elegans.},
  author={C. Michael Crowder},
  journal={Trends in neurosciences},
  volume={27 10},
A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca(2+)-activated K(+) channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release. 

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