Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa.

  title={Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa.},
  author={Brigitta M. Peskar and Kezia Lange and Udo Hoppe and Bernhard A. Peskar},
  volume={31 2},
Ethanol-induced gastric mucosal damage is characterized by microcirculatory changes such as stasis and plasma leakage. Sluggish blood flow and stasis have also been observed after administration of exogenous leukotriene (LT) C4. The effect of ethanol on the release of LTC4 from rat gastric mucosa was therefore investigated. It was found that intragastric instillation of ethanol increases gastric mucosal release of LTC4 in a dose- and time-dependent manner parallel to the production of gastric… CONTINUE READING


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