Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys

@article{Ferguson2013EthanolSA,
  title={Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys},
  author={Charmaine S. Ferguson and Sharon Miksys and Roberta M Palmour and Rachel F. Tyndale},
  journal={Neuropharmacology},
  year={2013},
  volume={72},
  pages={74-81}
}
CYP2B6 and CYP2E1 are enzymes responsible for the metabolism of many centrally acting drugs, toxins and endogenous compounds. Human smokers and alcoholics have elevated levels of CYP2B6 and CYP2E1 in certain brain regions, which may contribute to altered drug efficacy, neurotoxicity and metabolic tolerance. The objective of this study was to determine the effects of ethanol self-administration and nicotine treatment, alone and in combination, on brain CYP2B6 and CYP2E1 levels in monkeys… CONTINUE READING
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