Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats.

@article{Hsu2006EthanolRP,
  title={Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats.},
  author={Michael K H Hsu and Liang Qiao and Vikki Ho and Baohong Zhang and Hongxia Zhang and Narci C-H Teoh and Paul Dent and Geoffrey C. Farrell},
  journal={Journal of hepatology},
  year={2006},
  volume={44 2},
  pages={375-82}
}
BACKGROUND/AIMS Chronic ethanol consumption inhibits liver regeneration. We examined the effects of chronic ethanol consumption on two mitogen-activated protein kinases in relation to induction of cell cycle proteins after partial hepatectomy (PH). METHODS Male Wistar rats were ethanol-fed (EF) or pair-fed (PF) for 16 weeks before PH. Hepatic activation of extracellular signal regulated kinase (ERK)1/2, p38 kinase and expression of cyclinD1, cyclin-dependent kinase-4 (cdk4) and proliferating… CONTINUE READING

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