Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum.

@article{Carboni1993EthanolPT,
  title={Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum.},
  author={S Carboni and Raffaella Isola and Gian Luigi Gessa and Zvani Luigi Rossetti},
  journal={Neuroscience letters},
  year={1993},
  volume={152 1-2},
  pages={133-6}
}
The administration of ethanol (2 g/kg, i.p.) or of the non-competitive antagonist(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cycloepten-5,1 0-imine maleate (MK-801; 1 mg/kg, i.p.) induced a decrease in the extracellular concentrations of glutamate, as studied by microdialysis in the striatum of awake rats. Moreover, ethanol and MK-801 completely prevented the increase in extraneuronal glutamate concentration induced by the focal application of N-methyl-D-aspartate (NMDA). The present results… CONTINUE READING

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