Ethanol potentiation of calcium-activated potassium channels reconstituted into planar lipid bilayers.

@article{Chu1998EthanolPO,
  title={Ethanol potentiation of calcium-activated potassium channels reconstituted into planar lipid bilayers.},
  author={Benjamin Chu and Alex M Dopico and Jos{\'e}R. Lemos and Steven N. Treistman},
  journal={Molecular pharmacology},
  year={1998},
  volume={54 2},
  pages={
          397-406
        }
}
We examined the actions of ethanol on the single channel properties of large conductance Ca2+-activated K+ (BK) channels isolated from skeletal muscle T-tubule membranes and incorporated into planar lipid bilayer membranes. We have taken advantage of this preparation, because it lacks most elements of cellular complexity, including cytoplasmic constituents and complex membrane lipid composition and architecture, to examine the minimum requirements for the effects of alcohol. Clinically relevant… CONTINUE READING
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