• Medicine
  • Published in Cancer research 1991

Ethanol potentiates doxorubicin-induced inhibition of cell survival in cultured Chinese hamster ovary cells.

@article{Ganey1991EthanolPD,
  title={Ethanol potentiates doxorubicin-induced inhibition of cell survival in cultured Chinese hamster ovary cells.},
  author={Patricia E. Ganey and Ronald G. Thurman},
  journal={Cancer research},
  year={1991},
  volume={51 8},
  pages={
          2036-40
        }
}
Doxorubicin is an antineoplastic drug which undergoes oxidation-reduction cycling and produces toxicity to some cancer cell lines. Since oxidation-reduction cycling requires reducing equivalents and because ethanol metabolism via alcohol dehydrogenase (ADH) increases NADH, the effect of ethanol on doxorubicin toxicity was examined in cultured cells. Since some cells exhibit resistance to anthracyclines such as doxorubicin, two different Chinese hamster ovary cell lines were used, one sensitive… CONTINUE READING

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