Ethanol palatability and consumption by high ethanol-drinking rats: manipulation of the opioid system with naltrexone.

@article{Coonfield2004EthanolPA,
  title={Ethanol palatability and consumption by high ethanol-drinking rats: manipulation of the opioid system with naltrexone.},
  author={Daniel L Coonfield and Stephen W Kiefer and Frank Ferraro and John David Sinclair},
  journal={Behavioral neuroscience},
  year={2004},
  volume={118 5},
  pages={1089-96}
}
Three experiments examined the effect of acute naltrexone treatment on both taste reactivity and consumption of ethanol in high ethanol-preferring rat lines: Alko Alcohol-Accepting (AA) rats (Experiments 1 and 2) and Alcohol-Preferring (P) rats (Experiment 3). A 3.0 mg/kg naltrexone dose was ineffective at altering ethanol palatability for either line, whereas 7.5 mg/kg was effective at reducing palatability of 10% ethanol for AA, but not P, rats, as reflected by both a decrease in ingestive… CONTINUE READING