Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.

@article{Lieber1968EthanolOB,
  title={Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.},
  author={Charles S. Lieber and Leonore M Decarli},
  journal={Science},
  year={1968},
  volume={162 3856},
  pages={
          917-8
        }
}
Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol. 

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