Ethanol opens G-protein-activated inwardly rectifying K+ channels

  title={Ethanol opens G-protein-activated inwardly rectifying K+ channels},
  author={T. Kobayashi and Kazutaka Ikeda and H. Kojima and H. Niki and R. Yano and T. Yoshioka and T. Kumanishi},
  journal={Nature Neuroscience},
  • T. Kobayashi, Kazutaka Ikeda, +4 authors T. Kumanishi
  • Published 1999
  • Chemistry, Medicine
  • Nature Neuroscience
  • Ethanol affects many functions of the brain and peripheral organs. Here we show that ethanol opens G-protein-activated, inwardly rectifying K+ (GIRK) channels, which has important implications for inhibitory regulation of neuronal excitability and heart rate. At pharmacologically relevant concentrations, ethanol activated both brain-type GIRK1/2 and cardiac-type GIRK1/4 channels without interaction with G proteins or second messengers. Moreover, weaver mutant mice, which have a missense… CONTINUE READING
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