Ethanol opens G-protein-activated inwardly rectifying K+ channels
@article{Kobayashi1999EthanolOG, title={Ethanol opens G-protein-activated inwardly rectifying K+ channels}, author={Toru Kobayashi and Kazutaka Ikeda and Hiroshi Kojima and Hiroaki Niki and Ryoji Yano and Tohru Yoshioka and Toshiro Kumanishi}, journal={Nature Neuroscience}, year={1999}, volume={2}, pages={1091-1097} }
Ethanol affects many functions of the brain and peripheral organs. Here we show that ethanol opens G-protein-activated, inwardly rectifying K+ (GIRK) channels, which has important implications for inhibitory regulation of neuronal excitability and heart rate. At pharmacologically relevant concentrations, ethanol activated both brain-type GIRK1/2 and cardiac-type GIRK1/4 channels without interaction with G proteins or second messengers. Moreover, weaver mutant mice, which have a missense…
237 Citations
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