Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.

  title={Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.},
  author={Joseph T Alaimo and Scott J. Davis and Sam S Song and Christopher R Burnette and Mike Grotewiel and Keith L. Shelton and Jonathan T. Pierce-Shimomura and Andrew G. Davies and Jill C Bettinger},
  journal={Alcoholism, clinical and experimental research},
  volume={36 11},
BACKGROUND Ethanol (EtOH) is metabolized by a 2-step process in which alcohol dehydrogenase (ADH) oxidizes EtOH to acetaldehyde, which is further oxidized to acetate by aldehyde dehydrogenase (ALDH). Although variation in EtOH metabolism in humans strongly influences the propensity to chronically abuse alcohol, few data exist on the behavioral effects of altered EtOH metabolism. Here, we used the nematode Caenorhabditis elegans to directly examine how changes in EtOH metabolism alter behavioral… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Mutations affecting sensitivity to ethanol in the nematode, Caenorhabditis elegans.

Alcoholism, clinical and experimental research • 1995
View 5 Excerpts
Highly Influenced

High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 15 Excerpts
Highly Influenced

The genetics ofCaenorhabditis elegans. Genetics 77:71–94

S Brenner
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…