Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.

@article{Alaimo2012EthanolMA,
  title={Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.},
  author={Joseph T Alaimo and Scott J. Davis and Sam S Song and Christopher R Burnette and Mike Grotewiel and Keith L. Shelton and Jonathan T. Pierce-Shimomura and Andrew G. Davies and Jill C Bettinger},
  journal={Alcoholism, clinical and experimental research},
  year={2012},
  volume={36 11},
  pages={1840-50}
}
BACKGROUND Ethanol (EtOH) is metabolized by a 2-step process in which alcohol dehydrogenase (ADH) oxidizes EtOH to acetaldehyde, which is further oxidized to acetate by aldehyde dehydrogenase (ALDH). Although variation in EtOH metabolism in humans strongly influences the propensity to chronically abuse alcohol, few data exist on the behavioral effects of altered EtOH metabolism. Here, we used the nematode Caenorhabditis elegans to directly examine how changes in EtOH metabolism alter behavioral… CONTINUE READING

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