Ethanol metabolism, cirrhosis and alcoholism.

  title={Ethanol metabolism, cirrhosis and alcoholism.},
  author={Charles S. Lieber},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={257 1},
Alcohol-induced tissue damage results from associated nutritional deficiencies as well as some direct toxic effects, which have now been linked to the metabolism of ethanol. The main pathway involves liver alcohol dehydrogenase which catalyzes the oxidation of ethanol to acetaldehyde, with a shift to a more reduced state, and results in metabolic disturbances, such as hyperlactacidemia, acidosis, hyperglycemia, hyperuricemia and fatty liver. More severe toxic manifestations are produced by an… CONTINUE READING