Ethanol is a fast channel inhibitor of P2X4 receptors.

  title={Ethanol is a fast channel inhibitor of P2X4 receptors.},
  author={Olga Ostrovskaya and Liana Asatryan and Letisha R. Wyatt and Maya Popova and Kaixun Li and Robert W. Peoples and Ronald L. Alkana and Daryl L Davies},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={337 1},
P2X receptors (P2XRs) are ion channels gated by synaptically released ATP. The P2X4 is the most abundant P2XR subtype expressed in the central nervous system and to date is the most ethanol-sensitive. In addition, genomic findings suggest that P2X4Rs may play a role in alcohol intake/preference. However, little is known regarding how ethanol causes the inhibition of ATP-gated currents in P2X4Rs. We begin to address this issue by investigating the effects of ethanol in wild-type and mutant D331A… CONTINUE READING