Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.

@article{Chen2008EthanolIN,
  title={Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.},
  author={Suzhen Chen and Michael E. Charness},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 50},
  pages={19962-7}
}
The mechanisms by which ethanol damages the developing and adult central nervous system (CNS) remain unclear. Activity-dependent neuroprotective protein (ADNP) is a glial protein that protects the CNS against a wide array of insults and is critical for CNS development. NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas… CONTINUE READING