Ethanol inhibits NMDA-activated ion current in hippocampal neurons.

  title={Ethanol inhibits NMDA-activated ion current in hippocampal neurons.},
  author={David M. Lovinger and Gary D. White and Forrest F. Weight},
  volume={243 4899},
The ion current induced by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH). Inhibition increased in a concentration-dependent manner over the range 5 to 50 mM, a range that also produces intoxication. The amplitude of the NMDA-activated current was reduced 61 percent by 50 mM EtOH; in contrast, this concentration of EtOH reduced the amplitude of current activated by the glutamate receptor agonists kainate and… CONTINUE READING
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