Ethanol inhibition of spontaneous calcium release from isolated sarcoplasmic reticulum of alcoholic rats.


Ethanol is a well-recognized cause of muscle damage in humans. In vitro, ethanol decreases muscle fiber twitch tension by a mechanism unrelated to the electrical events of the motor endplates or muscle surface membranes. One possible explanation for this effect is a primary ethanol effect on calcium release from the sarcoplasmic reticulum (SR). Ethanol has… (More)