Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors.

@article{Steffensen2000EthanolIO,
  title={Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors.},
  author={Scott C Steffensen and Zhiguo Nie and Jos{\'e} Ramon Criado and George Robert Siggins},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 2},
  pages={637-47}
}
Ethanol alters N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid subtype A (GABA(A)) receptor-mediated neurotransmission. We have previously demonstrated that GABA(B) receptor blockade uncovers ethanol enhancement of GABA(A) responses in the hippocampus. Therefore, we evaluated in vivo and in vitro the role of GABA(B) receptors in ethanol-induced inhibition of neuronal activity as well as NMDA responses in the hippocampus, ventral tegmental area (VTA), and nucleus accumbens (NAcc), three… CONTINUE READING
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