Ethanol induces cell cycle arrest and triggers apoptosis via Sp1-dependent p75NTR expression in human neuroblastoma cells

@article{Do2013EthanolIC,
  title={Ethanol induces cell cycle arrest and triggers apoptosis via Sp1-dependent p75NTR expression in human neuroblastoma cells},
  author={Hang Do and Hey-Jin Park and Eun-Hwa Sohn and Byung-Oh Kim and Sung Hee Um and Jong-hwan Kwak and E Y Moon and Dong-Kwon Rhee and Suhkneung Pyo},
  journal={Cell Biology and Toxicology},
  year={2013},
  volume={29},
  pages={365-380}
}
Ethanol exposure has deleterious effects on the central nervous system. Although several mechanisms for ethanol-induced damage have been suggested, the precise mechanism underlying ethanol-induced neuronal cell death remains unclear. Recent studies indicate that the p75 neurotrophin receptor (p75NTR) has a critical role in the regulation of neuronal survival. This study was designed to examine the role of p75NTR in ethanol-induced apoptotic signaling in neuroblastoma cells. Ethanol caused… CONTINUE READING