Ethanol induces apoptosis in cerebellar granule neurons by inhibiting insulin-like growth factor 1 signaling.

@article{Zhang1998EthanolIA,
  title={Ethanol induces apoptosis in cerebellar granule neurons by inhibiting insulin-like growth factor 1 signaling.},
  author={Frank Xiaoling Zhang and Raphael Rubin and Thomas A Rooney},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 1},
  pages={196-204}
}
The ability of ethanol to interfere with insulin-like growth factor 1 (IGF-1)-mediated cell survival was examined in primary cultured cerebellar granule neurons. Cells underwent apoptosis when switched from medium containing 25 mM K+ to one containing 5 mM K+. IGF-1 protected granule neurons from apoptosis in medium containing 5 mM K+. Ethanol inhibited IGF-1-mediated neuronal survival but did not inhibit IGF-1 receptor binding or the neurotrophic action of elevated K+, and failed to potentiate… CONTINUE READING

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