Ethanol-induced iron mobilization: role of acetaldehyde-aldehyde oxidase generated superoxide.

  title={Ethanol-induced iron mobilization: role of acetaldehyde-aldehyde oxidase generated superoxide.},
  author={Sidney Shaw and Elizabeth Jayatilleke},
  journal={Free radical biology & medicine},
  volume={9 1},
Superoxide radicals, a species known to mobilize ferritin iron, and their interaction with catalytic iron have been implicated in the pathogenesis of alcohol-induced liver injury. The mechanism(s) by which ethanol metabolism generates free radicals and mobilizes catalytic iron, however, is not fully defined. In this investigation the role of hepatic aldehyde oxidase in the mobilization of catalytic iron from ferritin was studied in vitro. Iron mobilization due to the metabolism of ethanol to… CONTINUE READING


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