Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde.

@article{Siddiq1993EthanolinducedIO,
  title={Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde.},
  author={Tahir Siddiq and Peter James Richardson and William d. Mitchell and June Teare and Victor R. Preedy},
  journal={Cell biochemistry and function},
  year={1993},
  volume={11 1},
  pages={
          45-54
        }
}
  • Tahir Siddiq, Peter James Richardson, +2 authors Victor R. Preedy
  • Published in
    Cell biochemistry and…
    1993
  • Chemistry, Medicine
  • We have determined the extent to which acute ethanol administration perturbs the synthesis of ventricular contractile and non-contractile proteins in vivo. Male Wistar rats were treated with a standard dose of ethanol (75 mmol kg-1 body weight; i.p.). Controls were treated with isovolumetric amounts of saline (0.15 mol l-1 NaCl). Two metabolic inhibitors of ethanol metabolism were also used namely 4-methylpyrazole (alcohol dehydrogenase inhibitor) and cyanamide (acetaldehyde dehydrogenase… CONTINUE READING

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